Amphetamine is understood to inhibit monoamine oxidase, whereas the flexibility of amphetamine and its metabolites to inhibit various P450 isozymes along with other enzymes has not been adequately elucidated. In vitro experiments with human microsomes show small inhibition of CYP2D6 by amphetamine and slight inhibition of CYP1A2, 2D6, and 3A4 by on